THE PITUITARY-ADRENAL RESPONSE TO PARADOXICAL SLEEP DEPRIVATION IS SIMILAR TO A PSYCHOLOGICAL STRESSOR, WHEREAS THE HYPOTHALAMIC RESPONSE IS UNIQUE

The Pituitary-Adrenal Response to Paradoxical Sleep Deprivation Is Similar to a Psychological Stressor, Whereas the Hypothalamic Response Is Unique

Stressors of different natures induce activation of the hypothalamic-pituitary-adrenal (HPA) axis at different magnitudes.Moreover, the HPA axis response to repeated exposure is usually distinct from that elicited by a single session.Paradoxical sleep deprivation (PSD) augments ACTH and corticosterone (CORT) levels, but the nature of this stimulus

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Promises, pitfalls, and basic guidelines for applying machine learning classifiers to psychiatric imaging data, with autism as an example

Most psychiatric disorders are associated with subtle alterations in brain function and are subject to large inter-individual differences.Typically the diagnosis of these disorders requires time-consuming behavioral assessments administered by a multi-disciplinary team with extensive experience.Whilst the application of machine learning classificat

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3-oxoacyl-ACP reductase from Schistosoma japonicum: integrated in silico-in vitro strategy for discovering antischistosomal lead compounds.

BACKGROUND: Schistosomiasis is a disease caused by rab fire rated wafer parasitic worms and more than 200 million people are infected worldwide.The emergence of resistance to the most commonly used drug, praziquantel (PZQ), makes the development of novel drugs an urgent task.3-oxoacyl-ACP reductase (OAR), a key enzyme involved in the fatty acid syn

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